PHS SF424 (R&R) Adobe Forms Version B Application Guide
Part I: Instructions for Preparing and Submitting the Application
include how the data will be collected, analyzed, and
interpreted as well as any resource sharing plans as
Discuss potential problems, alternative strategies, and
benchmarks for success anticipated to achieve the aims.
If the project is in the early stages of development, describe
any strategy to establish feasibility, and address the
management of any high risk aspects of the proposed work.
Point out any procedures, situations, or materials that may be
hazardous to personnel and precautions to be exercised. A full
discussion on the use of select agents should appear in Item
If an applicant has multiple Specific Aims, then the applicant may address
Significance, Innovation and Approach for each Specific Aim
individually, or may address Significance, Innovation and Approach for
all of the Specific Aims collectively.
As applicable, also include the following information as part of the
Research Strategy, keeping within the three sections listed above:
Significance, Innovation, and Approach.
Preliminary Studies for New Applications: For new applications,
include information on Preliminary Studies. Discuss the PD/PI’s
preliminary studies, data, and or experience pertinent to this application.
Except for Exploratory/Developmental Grants (R21/R33), Small Research
Grants (R03), and Academic Research Enhancement Award (AREA)
Grants (R15), preliminary data can be an essential part of a research grant
application and help to establish the likelihood of success of the proposed
project. Early Stage Investigators should include preliminary data
(however, for R01 applications, reviewers will be instructed to place less
emphasis on the preliminary data in application from Early Stage
Investigators than on the preliminary data in applications from more
Progress Report for Renewal and Revision Applications. For
renewal/revision applications, provide a Progress Report. Provide the
beginning and ending dates for the period covered since the last
competitive review. Summarize the specific aims of the previous project
period and the importance of the findings, and emphasize the progress
made toward their achievement. Explain any significant changes to the
specific aims and any new directions including changes to the specific
aims and any new directions including changes resulting from significant
budget reductions. A list of publications, patents, and other printed
materials should be included in Item 5 (Progress Report Publication List);
do not include that information here.
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