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WSI ZoomViewer 
A Vendor Neutral HTML5 Whole Slide Image Viewer 
E Tseytlin, MS (University of Pittsburgh), Anil V. Parwani MD PhD MBA (UPMC), 
William Cable, MS (ISD), Liron Pantanowitz MD (UPMC) 
Funded by:  UPMC Shadyside Hospital Foundation 
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Digital Microscope Vendors 
Aperio 
Hamamatsu 
Trestle 
Zeiss 
Omnyx 
InterScope 
etc. etc. etc. 
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Problem of Choice 
No recognized medical digital imaging standard 
Limited or no interoperability between vendors 
Vendor lock-ins 
Software/ Hardware bundling 
Difficulty of integration of third-party products into institutions 
own digital imaging solutions 
Proprietary viewing software limits distribution and 
dissemination of digital imaging technology 
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UPMC Use Case 
Creation of two portals that require interaction with WSI from 
multiple vendors 
Difficulty of integration of third-party viewers for each  
vendor 
Different feature sets 
Inability to customize  
Inconsistent UI between viewers 
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Digital Pathology Consultation Portal 
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KingMed Pathology Consulting  
What is the solution? 
Integration of each proprietary viewer for each vendor without 
customizations and unified user interface 
OR 
Find or create an open source vendor agnostic WSI viewer 
OpenSlide 
OpenSlide is a product of the research 
group of M. Satyanarayanan (Satya) in 
the Carnegie Mellon University School 
of Computer Science. 
C library with Java and Python 
bindings 
Free and Open Source 
Has a basic Java client 
Can convert images to deep zoom 
format to display in OpenSeadragon 
HTML5 viewer 
Lacks HTTP image server  
Supports multiple vendors 
Aperio (.svs, .tif) 
Hamamatsu (.vms, .vmu, .ndpi) 
Leica (.scn) 
MIRAX (.mrxs) 
Sakura (.svslide) 
Trestle (.tif) 
Generic tiled TIFF (.tif) 
http://openslide.org/ 
SlideViewer 
Developed at University of Pittsburgh as 
part of SlideTutor ITS project 
Java WSI viewer that supports multiple 
WSI vendors 
Can interface directly with Aperio, 
Hamamatsu, Trestle WSI servers 
Can interface with OpenSlide WSI server 
(a separate component) 
Has an extensive Application 
Programming Interface (API) for ease of 
integration into other software 
PathConsult Viewer 
Java based viewer (applet) based 
on SlideViewer API  
Connects to OpenSlide Server 
Connects to Aperio, Hammatsu, 
Trestle proprietary image server 
software 
Upload snapshots for later review 
Non-persistent slide annotations 
Doesn't require additional 
software to be installed on sites 
that request consultation 
Hierarchical slide chooser in each 
case 
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