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WSI ZoomViewer 
A Vendor Neutral HTML5 Whole Slide Image Viewer 
E Tseytlin, MS (University of Pittsburgh), Anil V. Parwani MD PhD MBA (UPMC), 
William Cable, MS (ISD), Liron Pantanowitz MD (UPMC) 
Funded by:  UPMC Shadyside Hospital Foundation 
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Digital Microscope Vendors 
●
Aperio 
●
Hamamatsu 
●
Trestle 
●
Zeiss 
●
Omnyx 
●
InterScope 
●
etc. etc. etc. 
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Problem of Choice 
●
No recognized medical digital imaging standard 
●
Limited or no interoperability between vendors 
●
Vendor lock-ins 
●
Software/ Hardware bundling 
●
Difficulty of integration of third-party products into institutions 
own digital imaging solutions 
●
Proprietary viewing software limits distribution and 
dissemination of digital imaging technology 
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UPMC Use Case 
Creation of two portals that require interaction with WSI from 
multiple vendors 
●
Difficulty of integration of third-party viewers for each  
vendor 
●
Different feature sets 
●
Inability to customize  
●
Inconsistent UI between viewers 
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Digital Pathology Consultation Portal 
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KingMed Pathology Consulting  
What is the solution? 
Integration of each proprietary viewer for each vendor without 
customizations and unified user interface 
OR 
Find or create an open source vendor agnostic WSI viewer 
OpenSlide 
OpenSlide is a product of the research 
group of M. Satyanarayanan (Satya) in 
the Carnegie Mellon University School 
of Computer Science. 
●
C library with Java and Python 
bindings 
●
Free and Open Source 
●
Has a basic Java client 
●
Can convert images to deep zoom 
format to display in OpenSeadragon 
HTML5 viewer 
●
Lacks HTTP image server  
●
Supports multiple vendors 
–
Aperio (.svs, .tif) 
–
Hamamatsu (.vms, .vmu, .ndpi) 
–
Leica (.scn) 
–
MIRAX (.mrxs) 
–
Sakura (.svslide) 
–
Trestle (.tif) 
–
Generic tiled TIFF (.tif) 
http://openslide.org/ 
SlideViewer 
●
Developed at University of Pittsburgh as 
part of SlideTutor ITS project 
●
Java WSI viewer that supports multiple 
WSI vendors 
●
Can interface directly with Aperio, 
Hamamatsu, Trestle WSI servers 
●
Can interface with OpenSlide WSI server 
(a separate component) 
●
Has an extensive Application 
Programming Interface (API) for ease of 
integration into other software 
PathConsult Viewer 
●
Java based viewer (applet) based 
on SlideViewer API  
●
Connects to OpenSlide Server 
●
Connects to Aperio, Hammatsu, 
Trestle proprietary image server 
software 
●
Upload snapshots for later review 
●
Non-persistent slide annotations 
●
Doesn't require additional 
software to be installed on sites 
that request consultation 
●
Hierarchical slide chooser in each 
case 
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